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PYR ET

Ethyl pyruvate

CAS: 617-35-6

Molecular Formula: C5H8O3

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PYR ET - Names and Identifiers

Name Ethyl pyruvate
Synonyms PAEE
PYR ET
ETHYL PYRUVATE
Ethyl pyruvate
RARECHEM AL BI 0116
ETHYL 2-OXOPROPANOATE
ethyl 2-oxopropanoate
Ethyl 2-oxopropionate
ETHYL 2-OXOPROPIONATE
ETHYL 2-OXOPROPRIONATE
PYRUVIC ACID ETHYL ESTER
Pyruvic acid ethyl ester
Brenztraubensaeure-ethylester
Ethyl pyruvate,(Pyruvic acid ethyl ester)
CAS 617-35-6
EINECS 210-511-2
InChI InChI=1/C5H8O3/c1-3-8-5(7)4(2)6/h3H2,1-2H3
InChIKey XXRCUYVCPSWGCC-UHFFFAOYSA-N

PYR ET - Physico-chemical Properties

Molecular FormulaC5H8O3
Molar Mass116.12
Density1.045 g/mL at 25 °C (lit.)
Melting Point-58 °C
Boling Point144 °C (lit.)
Flash Point114°F
JECFA Number938
Water SolubilityMiscible with water, ethanol and ether.
Solubility 10g/l
Vapor Presure2.36hPa at 25℃
AppearanceLiquid
ColorClear pale yellow
Merck14,8021
BRN1071466
Storage ConditionStore at +2°C to +8°C.
StabilityVolatile
Refractive Indexn20/D 1.404(lit.)
Physical and Chemical PropertiesDensity 1.06
boiling point 144°C
refractive index 1.404-1.406
flash point 45°C
UseFor the manufacture of pharmaceutical indole Xinan and pesticide thiabendazole

PYR ET - Risk and Safety

Risk Codes10 - Flammable
Safety Description16 - Keep away from sources of ignition.
UN IDsUN 3272 3/PG 3
WGK Germany3
TSCAYes
HS Code29183000
Hazard NoteFlammable/Irritant
Hazard Class3
Packing GroupIII
ToxicityLD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rat > 2000 mg/kg

PYR ET - Reference Information

FEMA2457 | ETHYL PYRUVATE
LogP0.435 at 22.5℃
NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
product description ethyl pyruvate (English pyruvate), molecular formula is CH3COCOOC2H5, also known as ethyl 2-oxopropionate, is a colorless and transparent liquid at room temperature, has fresh and sweet flower and fruit aroma, and can be used in the blending of flavors such as apples, citrus and chocolate. It is an extremely important organic synthesis intermediate. It is used in medicine (synthetic thiamine drugs), pesticides (herbicides produced by DuPont, thiamine fungicides), food (can be used as preservatives, preservatives, etc.), Cosmetics and other industries have a wide range of uses. Ethyl pyruvate has a good effect on inhibiting the formation of tyrosinase in the epidermis, so it can prevent the formation of epidermal melanin and whiten the skin. It can also be added to the air freshener as an efficient active ingredient, which can effectively remove ammonia and methyl mercaptan in the air, and the smell is fresh and natural. Ethyl pyruvate has excellent performance in forming heterocyclic compounds. It is a raw material and intermediate that is difficult to replace in pesticide synthesis. It is widely used in the synthesis of fungicides and herbicides. Oxazolone derivatives synthesized from ethyl pyruvate are also good fungicides, which can effectively inhibit and kill fungi at a concentration of 5.0 × 10-4. Pyruvate is the main raw material for the production of tryptophan, phenylalanine, protein sugar and vitamin B. It is the raw material for the biosynthesis of L-dopa (dopa is used to treat Parkinson's syndrome) is the starter of ethylene polymer It is also the raw material for the preparation of grain protectants. An efficient herbicide was synthesized from pyruvate. The herbicide has excellent selectivity, good removal effect on sedge, Setaria and other weeds, and is safe for crops. As a feed and food additive, it has a good antiseptic and fresh-keeping function. At present, a small amount of it is used in the preservation of feed and fruit wine in China. Ethyl pyruvate itself has a special fragrance, which can be used in flavors and fragrances. It is also an important raw material for synthetic resins and plastics. Pyruvate ester products can also be used as special solvents for electronic materials, and foreign demand for applications in this area has increased rapidly.
toxicity GRAS(FEMA).
usage limit FEMA(mg/kg): beverage 50; Cold drinks 20~150; Candy 35; Baked products 40. The right amount is limited (FDA,§ 172.515,2001).
use ethyl pyruvate is an intermediate of the fungicide thiabendazole.
Used in organic synthesis.
It can be used to manufacture medicine indole and pesticide thiabendazole. At the same time, it is an important pharmaceutical and chemical intermediate, widely used in medicine, pesticides, flavors and fragrances, food additives, air fresheners, fine chemicals and other industries. It can be used to synthesize cardiovascular dilators and other drugs; it can also be used for whitening and nourishing skin cosmetics, which can promote skin wound healing, prevent and treat skin diseases characterized by cracking, peeling and scaling; it can be used as an air freshener The high-efficiency active ingredient in it can effectively remove ammonia and methyl mercaptan in the air; it has a special fragrance, so it can be used in flavors and fragrances; it is also an important raw material for synthetic resins and plastics.
production method obtained by oxidation of ethyl lactate with potassium permanganate.
There are several preparation methods. Gas phase oxidation of ethyl lactate The gas phase oxidation of ethyl lactate is carried out in the presence of a catalyst, and MoO3 as a catalyst shows higher selectivity than other metal oxides. In addition, the binary oxide catalyst contains molybdenum oxides such as Fe2O3-MoO3 and TeO2-MoO3 for the synthesis of pyruvate. It has high selectivity (temperature 300 ℃, selectivity exceeds 90%). If SnO2-MoO3 is used as a catalyst, it can be carried out at a lower temperature of 250 ℃. SnO2-MoO3 catalyst can also be used as a catalyst for liquid phase oxidation of lactate. The reaction temperature is 130 ℃, the reaction time is 3h, the conversion rate of ethyl lactate is 38.4%, and the selectivity is 98.9% to generate ethyl pyruvate. Liquid phase oxidation of ethyl lactate ethyl lactate in the presence of a small amount of bromine as catalyst, and oxidation is carried out with H2O2 as oxidant. For example, 50% H2O2 is added dropwise to a stirred and illuminated dichloromethane solution containing ethyl lactate and bromine, the reaction temperature is 25 ℃, the H2O2 dropwise time is about 1.5h, and the reaction is continued for 3h after dropwise addition. The solution is neutralized with NaHCO3 and washed with Na2SO3 solution to destroy and remove ethyl lactate peroxide, then concentrate and distill under reduced pressure to obtain ethyl pyruvate. Acrylate oxide acrylate is oxidized to pyruvate by H2O2 in the presence of Cr or V compound catalyst. For example, isopropyl acrylate is stirred and added with H2O2 in acetonitrile solvent in the presence of chromium triacetoacetate. The reaction temperature is 50 ℃ for 8h to obtain isopropyl pyruvate. The selectivity is 99.1% and the conversion rate is 87.9%. Another example is methyl acrylate added to triethylamine in the presence of chromium triacetoacetate or chromic acid for 20h, the temperature is 40 ℃, the selective 72%, the conversion rate is 82%, and methyl pyruvate is obtained. In addition, acetone aldehyde and methanol react in the gas phase in the presence of nickel phosphate catalyst to obtain methyl pyruvate.
Last Update：2024-04-09 20:49:11
PYR ET
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JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.
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Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Guangzhou Yuanda New Material Co.,Ltd
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei Longxin Chemical Industry Co., Ltd
Spot supply
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276 Click to send a QQ message
Wechat: A2020071098
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Wuhan Xingzhongcheng Chemical limited company
Spot supply
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217 Click to send a QQ message
Wechat: 18627766980
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Zouping Mingxing Chemical Co., Ltd.
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Hubei Lansun Biochemistry Pharmaceutical Co., Ltd.
Product Name: Ethyl pyruvate Request for quotation
CAS: 617-35-6
Tel: 86-0714-6395877
Email: 3434522316@qq.com
Mobile: 13329920518
QQ: 3434522316 Click to send a QQ messageSend QQ message
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PYR ET
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